Data and Science with Glen Wright Colopy is a podcast covering critical scientific reasoning, particularly from a data science / machine learning / statistics perspective. Episodes typically focus on understanding of how to be better scientists and critical thinkers for the practical purpose of being a better data scientists. Previously called: ”Pod of Asclepius”
Episodes
Tuesday Feb 01, 2022
Tuesday Feb 01, 2022
Charlotte Deane | Bioinformatics, Deepmind's AlphaFold 2, and Llamas
#datascience #ai
Charlotte Deane (Oxford University) talks about statistical approaches to bioinformatics, the evolution of Google Deepmind's AlphaFold 2 & its place in protein informatics deep learning landscape. She also describes humanizing antibodies, and the increasing role of software engineers in statistical research groups. The topic of llamas, camels, and alpacas (and their unique place in proteomics research) makes a surprise visit.
[Note: This episode was originally published in January 2022, but the file contained a buffering error, which prevented the full interview from being played. This version, published Feb 1, 2022 contains the full interview.]
Topics
0:00 Intro / An important topic to debate
3:50 What is a protein? Why are proteins foundational?
13:32 Immunotherapies, humanizing antibodies, & creating an scientific databases
16:04 Translating in silico research into immunotherapies
21:03 Nanobodies, camels, alpacas, & llamas.
25:05:00 Databases and data knowledge bases
33:21:00 Targeted therapies
39:45:00 Statistical modeling in proteomics
45:40:00 DeepMind AlphaFold's evolution
55:28:00 Software engineers in academic research groups
1:03:21 The adventure of science
1:07:42 Oxford Blues hockey & scientific debate
Comments (1)
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You asked about the background of your listeners, adding that you expected them all to be scientists. I’m not! But I listened to this because my son has recently joined Ms Dean’s team - I believe as the first person selected to do so from outside her academic team - and I found it to be very interesting and illuminating about the work that he is doing, even if some of the content was beyond me. She is clearly a person of great expertise and shear brain power but also a great communicator.
Tuesday Dec 06, 2022
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